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| Growth factors are naturally occurring proteins that play an important role in cell differentiation during early embryonic development. These factors may also regulate cell growth and repair. Growth factors have been widely recognized as exciting new development opportunities in human therapeutics for serious muscular degenerative and metabolic diseases. From an agricultural perspective, growth factors offer the promise of products that will improve livestock production efficiency and animal health. The Company's lead growth factor technology is based on Myostatin, which is encoded by the GDF-8 gene. Myostatin is a potent regulator of skeletal muscle development. MetaMorphix® believes that Myostatin, due to its demonstrated potential to transform livestock production dynamics, is potentially the most important gene discovery in the history of livestock production and animal health. Under terms of an agreement involving MetaMorphix®, The Johns Hopkins University School of Medicine (JHU), and Genetics Institute (part of Wyeth Research Division), MetaMorphix® holds exclusive animal health development rights to commercialize Growth and Differentiation Factor (GDF) discoveries resulting from the research collaboration between Genetics Institute and Dr. Se-Jin Lee's laboratory at JHU.
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